Sorry you keep having trouble. We'd love to figure out what is going on.
Windows updates, virus scans, uninstalling apps, deleting files, etc may accidentally help but they are more like voodoo or shots in the dark. I suggest focusing on the specific problem and error messages. Especially if Spine can't lock files, using Lock Hunter will tell you what process is preventing Spine from locking the files.
Again most of your logs were the 4.0.37 launcher. Use the latest launcher.
BTW, you said you closed Windows Defender, but it is notorious for being difficult to stop. While Spine should work fine with Defender, there are tools like this if you want to try without Defender:
qtkite/defender-control