There is currently no official Spine runtime for Ren'Py, but there has been interest in creating one. The discussion on the Esoteric Software forum mentions that the team is focused on other priorities, such as the Spine 4.2 release, before they can work on new runtimes like Ren'Py. However, you could consider using a Python runtime for Spine, such as the one being developed for Pygame, as a starting point. This would involve either porting an existing core runtime to Python or wrapping an existing core runtime and exposing it to Python, as suggested in the forum discussions.
