Yes, Spine animations can be used with both the SkeletonMecanim and SkeletonAnimation components in Unity. The SkeletonMecanim component allows for the use of Unity's Mecanim animation system to control Spine animations, providing a high-level control in combination with the Spine animation system for posing and setup of the skeleton. This means that Spine bones are applicable and can be manipulated under both systems, although the way you interact with them might differ due to the nature of the SkeletonMecanim and SkeletonAnimation components. The SkeletonMecanim component is an alternative to SkeletonAnimation, using Unity's Mecanim for animation control, while SkeletonAnimation provides direct control over animations through the Spine API.
